Opportunity Information: Apply for RFA DK 23 019
The NIH funding opportunity "Integration of Novel Measures for Improved Classification of Type 2 Diabetes" (RFA-DK-23-019) is a cooperative agreement (U01) designed to build a coordinated research consortium focused on improving how type 2 diabetes (T2D) is classified. Instead of treating T2D as a single, uniform condition, the initiative is centered on integrating multiple kinds of data to better stratify individuals into biologically and clinically meaningful subtypes. A key emphasis is bringing together diverse investigative teams who can combine existing and emerging measures, including markers that reflect organ or tissue function, and then incorporate those measures into modern analytic approaches that can refine disease definitions.
The scientific purpose is twofold. First, the consortium is expected to develop a broadly applicable framework for identifying T2D subtypes that can be used across studies and populations, not just within one dataset or one institution's approach. Second, it aims to deepen understanding of the physiologic drivers behind those subtypes, meaning the underlying biological processes that differentiate one subtype from another. The longer-term intent is that clearer subtyping will make it easier to design and match more effective precision interventions, where prevention or treatment strategies can be tailored to the dominant mechanisms driving disease in a given person rather than relying on a one-size-fits-all model.
Because this is a U01 cooperative agreement, projects funded under this announcement are typically expected to operate in a more collaborative, NIH-involved structure than standard research grants. In practical terms, this mechanism generally supports multi-team coordination, shared standards, and joint problem-solving across the consortium to ensure that integrated data resources, analytic methods, and resulting subtype frameworks are interoperable and broadly useful. The NOFO explicitly notes that clinical trials are not allowed, which signals that the work should focus on classification, integration of measures, analysis strategies, and mechanistic understanding rather than testing clinical interventions in a trial design under this award.
The opportunity falls under the NIH and is categorized under health and nutrition-related research (CFDA 93.847). The posted award ceiling is $500,000, and the original closing date listed is October 26, 2023. While the summary does not detail the number of awards, it indicates "ExpectedAwards:" without a value, so applicants typically would need to consult the full NOFO for definitive expectations about how many projects NIH planned to support, the intended consortium structure, and any coordinating components.
Eligibility is broad and spans many organization types, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and other eligible entities. The NOFO also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
There are important limits related to foreign participation. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as applicants. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S.-based applicant organization can include certain foreign collaborations or performance sites if they meet NIH's definition and requirements for a foreign component. This structure encourages broad scientific collaboration while keeping the applicant organization and primary award management within eligible U.S.-based institutions.
Overall, the grant is focused on building shared, integrative scientific capabilities to move T2D classification beyond traditional labels and toward data-driven, mechanism-based subtypes. By combining varied data types, especially organ- and tissue-function markers, and embedding them in advanced analytic strategies, the consortium is intended to produce a framework that is widely usable and that improves understanding of why T2D differs from person to person, setting the stage for more targeted, effective precision approaches in the future without directly conducting clinical trials under this specific award.Apply for RFA DK 23 019
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Integration of Novel Measures for Improved Classification of Type 2 Diabetes (U01, Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2023-05-31.
- Applicants must submit their applications by 2023-10-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: Integration of Novel Measures for Improved Classification of Type 2 Diabetes (RFA-DK-23-019)
What is the NIH funding opportunity RFA-DK-23-019 about?
RFA-DK-23-019, titled "Integration of Novel Measures for Improved Classification of Type 2 Diabetes," supports a coordinated research consortium to improve how type 2 diabetes (T2D) is classified. The central idea is to move beyond treating T2D as a single uniform condition by integrating multiple kinds of data to identify biologically and clinically meaningful subtypes.
What funding mechanism does this opportunity use?
This opportunity uses a cooperative agreement mechanism (U01). Under a U01, NIH typically has substantial involvement, and funded teams are generally expected to coordinate closely with NIH and other awardees as part of a consortium.
What is the main goal of the consortium?
The consortium is intended to build shared, integrative scientific capabilities that enable improved stratification of people with T2D into meaningful subtypes. This includes bringing together diverse teams to combine existing and emerging measures and to incorporate those measures into modern analytic approaches that refine disease definitions.
What are the two major scientific purposes described for this initiative?
The initiative has two key scientific aims: (1) develop a broadly applicable framework for identifying T2D subtypes that can be used across studies and populations, and (2) deepen understanding of the physiologic drivers behind those subtypes, meaning the biological processes that distinguish one subtype from another.
How does this opportunity approach type 2 diabetes differently than traditional models?
Instead of treating T2D as a single diagnosis with relatively uniform underlying biology, this initiative emphasizes integrating diverse data types to better classify T2D into subtypes that reflect different biological mechanisms and clinical patterns.
What kinds of measures or data does the NOFO emphasize integrating?
The description emphasizes integrating multiple kinds of data, including existing and emerging measures and markers that reflect organ or tissue function, and then using modern analytic approaches to improve classification and subtype definitions.
Why is the initiative focused on identifying subtypes of T2D?
The longer-term intent is that clearer subtyping will support more effective precision interventions by making it easier to tailor prevention or treatment strategies to the dominant mechanisms driving disease in a given person, rather than relying on one-size-fits-all approaches.
Are clinical trials allowed under this funding opportunity?
No. The NOFO explicitly states that clinical trials are not allowed. The work is expected to focus on classification, integration of measures, analytic strategies, and mechanistic understanding rather than testing interventions through clinical trial designs under this award.
What does it mean that this is a cooperative agreement (U01) rather than a standard research grant?
A U01 cooperative agreement typically involves a more collaborative, NIH-involved structure than many standard research grants. In this opportunity, that structure is described as supporting multi-team coordination, shared standards, and joint problem-solving across the consortium so that data resources, analytic methods, and subtype frameworks are interoperable and broadly useful.
What is the award ceiling for this opportunity?
The posted award ceiling is $500,000.
What is the original closing date listed in the summary?
The original closing date listed is October 26, 2023.
Does the summary specify how many awards NIH expects to make?
No. The summary indicates "ExpectedAwards:" but does not provide a value. Applicants would typically need to consult the full NOFO for definitive details on the number of awards and how the consortium is expected to be structured.
Which agency is offering this funding opportunity?
The opportunity falls under the National Institutes of Health (NIH).
What is the CFDA number and general research area for this opportunity?
The opportunity is categorized under health and nutrition-related research and is listed with CFDA 93.847.
What types of U.S. organizations are eligible to apply?
Eligibility is broad and includes many organization types, such as state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and other eligible entities.
Are minority-serving institutions and community-based organizations included in the eligible applicant types?
Yes. The NOFO highlights additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Are non-U.S. (foreign) organizations allowed to apply as the main applicant?
No. Non-domestic (non-U.S.) entities are not eligible to apply as applicants. In addition, non-domestic components of U.S. organizations are not eligible to apply as applicants.
Can a U.S.-based applicant include foreign collaborations or work performed outside the U.S.?
Yes, foreign components are allowed as defined by the NIH Grants Policy Statement. This means a U.S.-based applicant can include certain foreign collaborations or performance sites if they meet NIH's definition and requirements for a foreign component.
What is the practical emphasis of the consortium work described in the summary?
The emphasis is on building shared capabilities: integrating diverse measures (including organ- and tissue-function markers), applying modern analytic methods, creating interoperable standards and approaches across teams, and producing subtype frameworks that are broadly usable across studies and populations.
What is the anticipated long-term impact of the work, according to the summary?
The long-term intent is to enable more targeted and effective precision approaches by improving T2D subtyping and understanding the biological mechanisms that drive differences among individuals with T2D, while not directly conducting clinical trials under this award.
Browse more opportunities from the same category: Food and Nutrition, Health
Next opportunity: Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01 Clinical Trial Optional)
Previous opportunity: BJA FY 23 Transforming Prison Cultures, Climates, and Spaces
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA DK 23 019
Applicants also applied for:
Applicants who have applied for this opportunity (RFA DK 23 019) also looked into and applied for these:
| Funding Opportunity |
|---|
| Integration of Novel Measures for Improved Classification of Type 2 Diabetes Biostatistics Research Center (U01 Clinical Trial Not Allowed) Apply for RFA DK 23 020 Funding Number: RFA DK 23 020 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Undergraduate Summer Research Education in Kidney, Urologic, and Hematologic Diseases (R25 Clinical Trial Not Allowed) Apply for RFA DK 23 013 Funding Number: RFA DK 23 013 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $130,000 |
| Human Islet Research Enhancement Center for the Human Islet Research Network (U24 Clinical Trial Not Allowed) Apply for RFA DK 23 008 Funding Number: RFA DK 23 008 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,200,000 |
| NIDDK Catalyst Award (DP1 Clinical Trial Not Allowed) Apply for RFA DK 23 014 Funding Number: RFA DK 23 014 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Single Source for the Continuation of Cure Glomerulonephropathy (CureGN) Data Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA DK 22 513 Funding Number: RFA DK 22 513 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Participating Clinical Centers (U01 Clinical Trial Not Allowed) Apply for RFA DK 22 512 Funding Number: RFA DK 22 512 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| A Consortium for Gut-Brain Communication in Parkinsons Disease (U01 Clinical Trial Not Allowed) Apply for RFA DK 22 036 Funding Number: RFA DK 22 036 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $300,000 |
| A Consortium for Gut-Brain Communication in Parkinsons Disease (U24 Clinical Trial not allowed) Apply for RFA DK 23 001 Funding Number: RFA DK 23 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $400,000 |
| Institutional Network Award for Promoting Kidney, Urologic, and Hematologic Research Training (U2C - Clinical Trial Not Allowed) Apply for PAR 23 248 Funding Number: PAR 23 248 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Single Source for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center (U24 Clinical Trial Required) Apply for RFA DK 23 516 Funding Number: RFA DK 23 516 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Continuation of the Childhood Liver Disease Research Network (ChiLDReN) Scientific and Data Coordinating Center (U24 Clinical Trial Optional) Apply for RFA DK 23 018 Funding Number: RFA DK 23 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Centers (U01 Clinical Trial Required) Apply for RFA DK 23 515 Funding Number: RFA DK 23 515 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Continuation of the Childhood Liver Disease Research Network (ChiLDReN) Clinical Centers (U01 Clinical Trial Required) Apply for RFA DK 23 017 Funding Number: RFA DK 23 017 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIAID and NIDDK Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional) Apply for PAR 23 275 Funding Number: PAR 23 275 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R61/R33 Basic Experimental Studies with Humans Required) Apply for RFA DA 24 034 Funding Number: RFA DA 24 034 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Human Islet Research Network - Consortium on Modeling Autoimmune Diabetes (HIRN-CMAD) (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA DK 23 004 Funding Number: RFA DK 23 004 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional) Apply for RFA DK 25 003 Funding Number: RFA DK 25 003 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Single Source for continuation of the Human Pancreas Analysis Program for Type-2 Diabetes (HPAP-T2D) (U01 Clinical Trial Not Allowed) Apply for RFA DK 25 002 Funding Number: RFA DK 25 002 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,000,000 |
| Addressing the Impact of Syndemics on the Health of People with HIV and Diseases and Conditions within the Missions of NIDDK and NHLBI (R01 Clinical Trial Optional) Apply for RFA DK 25 001 Funding Number: RFA DK 25 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Cardiovascular Repository Type 1 Diabetes (CARE-T1D) Consortium (U01 Clinical Trial Not Allowed). Apply for RFA DK 23 021 Funding Number: RFA DK 23 021 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA DK 23 019", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.