Opportunity Information: Apply for PAR 18 329
Technology to Detect, Monitor and Assess Daily Functions in Individuals with Cognitive Decline, Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD) is a Small Business Innovation Research (SBIR) grant opportunity from the National Institutes of Health (NIH) designed to push forward practical technologies that can track real-world daily functioning in people who are at risk for, or already living with, Alzheimer's disease or related dementias. The focus is on research and development of tools such as wearables, mobile-based systems, and other technology platforms (including software applications) that can collect continuous, real-time or near-real-time data. Rather than relying only on occasional clinic visits or self-reported questionnaires, the goal is to capture objective, ongoing measures that reflect how someone is functioning day to day, which can be especially valuable for detecting subtle changes over time.
The announcement emphasizes technologies that measure variables tied to activities of daily living and everyday function, which are often among the earliest and most meaningful indicators of cognitive decline. In practice, this could include passive or active monitoring of mobility and gait, sleep patterns, daily routines, navigation and wayfinding, medication adherence behaviors, communication patterns, or other measurable signals that reflect independence and cognitive health. The opportunity is aimed at building and validating technology that can generate usable, continuous data streams, potentially enabling earlier identification of decline, better monitoring of progression, and improved assessment of outcomes that matter to patients and caregivers.
This funding opportunity uses the SBIR R43/R44 mechanism, meaning it supports small businesses through the typical phased innovation pipeline. Phase I (R43) generally supports early feasibility and proof-of-concept work, while Phase II (R44) supports further development, refinement, and steps toward commercialization or broader deployment. Importantly, the FOA is labeled "Clinical Trial Not Allowed," which signals that applicants should not propose NIH-defined clinical trials under this specific announcement. Work can still involve human-centered development and testing activities, but proposals need to be structured to remain outside the NIH definition of a clinical trial for this FOA, which affects how studies are designed and described.
Eligibility is restricted to small businesses, consistent with SBIR rules, and there are clear limits related to foreign involvement. Non-U.S. entities (foreign institutions) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, may be allowed in some circumstances, meaning a U.S. small business might be able to include certain foreign elements if they meet NIH policy requirements and are appropriately justified.
From an administrative standpoint, this is a discretionary grant opportunity in the health funding area, listed under CFDA number 93.866, and it was originally posted with the funding opportunity number PAR 18 329. The original closing date shown is 2020-01-05, and the source data lists an award ceiling of $350,000. The listing also notes "ExpectedAwards" without a specified number, suggesting that the exact number of awards may depend on appropriations, application volume, and overall NIH priorities at the time of funding decisions.
Overall, the opportunity targets the development of scalable, real-world monitoring technologies that can translate behavioral and functional data into meaningful indicators of cognitive health and daily functioning in AD/ADRD populations. It is oriented toward innovation that can move beyond episodic measurement and toward continuous, objective assessment, while fitting the SBIR model of building commercially viable tools that can ultimately be deployed in home, community, or care settings.Apply for PAR 18 329
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technology to Detect, Monitor and Assess Daily Functions in Individuals with Cognitive Decline, Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD) (R43/R44 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2017-10-25.
- Applicants must submit their applications by 2020-01-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: Small businesses.
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| Funding Opportunity |
|---|
| Technology to Detect, Monitor and Assess Daily Functions in Individuals with Cognitive Decline, Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD) (R41/R42 Clinical Trial Not Allowed) Apply for PAR 18 326 Funding Number: PAR 18 326 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| Immunity in the Elderly (R01) Clinical Trial Optional Apply for RFA AI 17 037 Funding Number: RFA AI 17 037 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Enhancing Central Neural Control of Mobility in Aging (U01 Clinical Trial Optional) Apply for RFA AG 18 019 Funding Number: RFA AG 18 019 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required) Apply for PAR 18 406 Funding Number: PAR 18 406 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Role of Peripheral Proteostasis on Brain Aging and Alzheimer's Disease (R01 Clinical Trial Not Allowed) Apply for RFA AG 18 020 Funding Number: RFA AG 18 020 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3) - Clinical Trial Required Apply for PAR 18 407 Funding Number: PAR 18 407 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01) - (Clinical Trials Not Allowed) Apply for RFA HL 18 026 Funding Number: RFA HL 18 026 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Clarifying the Relationship between Delirium and Alzheimers Disease and Related Dementias (R01 Clinical Trial Optional) Apply for PAR 18 029 Funding Number: PAR 18 029 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Phase III Clinical Trials for the Spectrum of Alzheimer's Disease and Age-related Cognitive Decline (R01 Clinical Trial Required) Apply for PAR 18 028 Funding Number: PAR 18 028 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIA Revision and Resubmission Program Project Applications (P01 Clinical Trial Optional) Apply for PAR 18 030 Funding Number: PAR 18 030 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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| Phenotypic and Functional Studies on FOXO3 Human Longevity Variants to Inform Potential Therapeutic Target Identification Research (R01 Clinical Trial Optional) Apply for PAR 18 026 Funding Number: PAR 18 026 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) Apply for PAR 18 296 Funding Number: PAR 18 296 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIA Program Project Applications (P01 Clinical Trial Optional) Apply for PAR 18 297 Funding Number: PAR 18 297 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| 93.067 Apply for CDC RFA GH13 1368A Funding Number: CDC RFA GH13 1368A Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
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