Opportunity Information: Apply for PAS 19 393
The National Institutes of Health (NIH), within the U.S. Department of Health and Human Services, offered a discretionary grant opportunity titled "Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Systems Biology (R03 Clinical Trial Not Allowed)" under funding opportunity number PAS-19-393. The program uses the NIH R03 mechanism, which is designed to fund small, focused projects that can generate early evidence, feasibility data, or proof-of-concept results. As framed here, the emphasis is on systems biology approaches that can produce new scientific insight relevant to Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD), with the practical aim of improving prevention strategies, diagnostic methods, treatments, and overall care.
A central purpose of this opportunity is workforce and field development. NIH explicitly targets two groups: first, the next generation of U.S.-based researchers who are building research and academic careers in neuroscience, AD/ADRD, and healthy brain aging; and second, established investigators who are not currently working in AD/ADRD but have expertise that could be translated into the dementia space. For the latter group, the R03 is positioned as a way to run pilot studies that can seed a new line of AD/ADRD research, leveraging an investigator’s existing tools, models, datasets, or methodological strengths to open up innovative directions in systems biology.
The science focus is systems biology, meaning applicants are expected to look beyond single molecules or isolated pathways and instead study AD/ADRD as complex, interacting biological systems. In practice, this often includes integrative or multi-level approaches that connect molecular, cellular, circuit, and organismal processes, potentially incorporating computational modeling, network analyses, multi-omics integration, or other methods that help explain how interacting biological components contribute to disease onset, progression, heterogeneity, and clinical outcomes. The opportunity description stresses that the funded projects should address areas where additional scientific insight is needed, which fits the R03 role of enabling exploratory work that clarifies mechanisms, identifies new hypotheses, or tests novel approaches before larger-scale follow-on studies.
The award parameters included an award ceiling of $100,000, with an anticipated 12 awards. The opportunity’s original closing date was November 16, 2022, and the creation date was October 7, 2019. The activity category is Health, and the associated CFDA number listed is 93.866. Importantly, the notice specifies "Clinical Trial Not Allowed," meaning applicants must propose research that does not meet NIH’s definition of a clinical trial; the work can still be clinically relevant and may involve human data or samples depending on the specific study design, but it cannot be structured as a clinical trial with prospective assignment to an intervention to evaluate effects on health-related outcomes.
Eligibility is broad and includes many types of domestic organizations. Eligible applicants listed include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other entities as described in NIH’s additional eligibility language. The program also explicitly encourages applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities, consistent with NIH’s broader goals to expand participation and representation in biomedical research.
Overall, this R03 opportunity was structured as a relatively small, accessible entry point for generating high-value pilot data in AD/ADRD systems biology. It aimed to both accelerate early-career development and draw new investigators into Alzheimer’s and dementia research, supporting innovative ideas that could later scale into larger projects and sustained research programs focused on healthier brain aging and improved outcomes for people affected by AD/ADRD.Apply for PAS 19 393
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Systems Biology (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Oct 07, 2019.
- Applicants must submit their applications by Nov 16, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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