Opportunity Information: Apply for RFA IP 22 004
The grant opportunity titled "US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings" is a CDC-led effort to fund a coordinated US network that can reliably measure how well respiratory virus vaccines work in real-world outpatient care. The central public health problem driving the program is that influenza, COVID-19, and other respiratory viruses continue to cause substantial illness, death, and strain on healthcare systems across every age group. Because vaccines are rolled out nationally and updated over time (for example, seasonal flu vaccines and evolving COVID-19 products), public health leaders need consistent, timely, and accurate vaccine effectiveness estimates to understand the protection achieved by these vaccination programs and to inform future policy, clinical guidance, and vaccine strategy.
At its core, the funded platform is meant to generate high-quality, laboratory-confirmed evidence on vaccine performance against medically attended acute respiratory illness in ambulatory settings, meaning outpatient clinics and similar non-hospital environments where people seek care for acute symptoms. The CDC is specifically looking to support institutions that can do three things well and at scale: first, systematically test enrolled patients for influenza, SARS-CoV-2, and other respiratory viruses using laboratory methods (so outcomes are confirmed rather than assumed); second, obtain dependable vaccination records for those patients (so the analysis compares vaccinated and unvaccinated groups accurately); and third, produce credible estimates of vaccine effectiveness for respiratory virus vaccines, including flu and COVID-19 vaccines, focused on preventing medically attended illness in the populations for whom vaccination is recommended. The emphasis on systematic testing and reliable vaccination documentation reflects a key challenge in vaccine effectiveness work: weak or inconsistent testing practices and incomplete vaccination histories can distort results, so the platform is designed to standardize and strengthen those inputs.
This is a discretionary funding opportunity from the US Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), administered through ERA. The funding instrument is a cooperative agreement, which typically means the CDC expects substantial involvement during the period of performance, such as collaborating on study design elements, standardized protocols, data sharing approaches, analytic methods, and reporting timelines. The opportunity is categorized under the health activity area and is associated with CFDA numbers 93.083 and 93.185. The CDC planned an estimated eight awards, with an award ceiling of $9,100,000, indicating support for multiple sites or institutions that together form a broader national measurement network rather than a single standalone study location.
Eligibility is intentionally broad to accommodate the range of organizations that could contribute to a national platform. Eligible applicants include various levels of government (state, county, city/township, special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those specific nonprofit categories), for-profit organizations other than small businesses, small businesses, and other entities as clarified in the opportunity text. This wide eligibility aligns with the operational reality that outpatient respiratory illness surveillance and vaccine effectiveness studies often rely on partnerships among public health agencies, academic centers, healthcare delivery systems, and laboratories.
In practical terms, this funding opportunity is about building and sustaining an infrastructure that can quickly translate outpatient testing results and vaccination histories into actionable estimates of how well vaccines are preventing symptomatic, medically attended respiratory disease. Those estimates can help decision-makers evaluate the impact of vaccination campaigns, compare effectiveness across seasons or viral variants, and identify gaps in protection that might require updated vaccines, targeted outreach, or complementary public health measures. The opportunity was created on March 8, 2022, and the original application closing date was May 4, 2022, with electronic submissions due by 5:00 pm ET on the due date.Apply for RFA IP 22 004
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.083, 93.185.
- This funding opportunity was created on Mar 08, 2022.
- Applicants must submit their applications by May 04, 2022 Electronically submitted applications must be submitted no later than 500#160pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $9,100,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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